Wuhan Jinglong Biotechnology Achieves Fruitful Results Through Two-Way Exchanges with the State Key Laboratory of Membrane Biology at Tsinghua University, Officially Launching R&D Project for Exosome Oral Dispersible Films

In October 2025, Wuhan Jinglong Biotechnology Co., Ltd. conducted in-depth two-way technical exchanges with the State Key Laboratory of Membrane Biology, Tsinghua University. The core team of Jinglong Biotechnology took the lead in visiting the laboratory for technical training, followed by an on-site inspection by the laboratory’s expert team at Jinglong Biotechnology. Based on their technological complementarity, the two parties reached a high-level consensus on cooperation, focusing on in-depth collaboration in the field of membrane biology to advance the R&D and industrialization of exosome (extracellular vesicle) oral dispersible films.

This cooperation will leverage Jinglong Biotechnology’s mature experience in oral dispersible film production and industrial production line advantages, combined with the laboratory’s cutting-edge research strength in membrane biology, to jointly break through industry bottlenecks in exosome oral formulations and promote the transformation of membrane biology research achievements into industrial applications.

The State Key Laboratory of Membrane Biology at Tsinghua University is a national-level key laboratory dedicated to membrane biology research in China, with significant influence in the international life and health sector. The laboratory focuses on core fields including the systematic R&D of novel membrane biology technologies, drug target structure analysis, and AI-based analysis of biological macromolecules. It has led the establishment of China’s first structural biology database and possesses top-tier technological reserves in membrane structure analysis, high-purity extraction of plant exosomes, and AI-assisted drug design, aiming to break through bottlenecks in transforming scientific and technological achievements into practical productivity.

This in-depth cooperation originated from technical mutual recognition through two-way exchanges. Wuhan Jinglong Biotechnology organized its core R&D and production team to the State Key Laboratory of Membrane Biology at Tsinghua University, systematically studying the laboratory’s cutting-edge research achievements in exosome separation and purification, membrane protein structure analysis, and cryo-electron microscopy ultrastructure imaging. The team gained in-depth insights into the R&D and preparation technologies of plant exosome raw materials, laying a solid foundation for technical collaboration between the two parties.

Following Jinglong Biotechnology’s visit to the laboratory, the expert team from the State Key Laboratory of Membrane Biology at Tsinghua University promptly conducted an on-site inspection at Wuhan Jinglong Biotechnology, with a focus on visiting the company’s GMP workshop, fully automatic dedicated oral dispersible film production line, and supporting R&D and testing center. The testing center is equipped with high-precision instruments such as Agilent High-Performance Liquid Chromatography (HPLC) and PerkinElmer Atomic Absorption Spectrometry.

During the inspection, Jinglong Biotechnology comprehensively demonstrated its mature production experience in oral dispersible film formulations, including core technologies such as nanodispersion technology, optimization of film mechanical strength, and establishment of disintegration kinetic models, as well as industrial capabilities including micron-level finished product quality control, customized pretreatment processes, and development of gradient-disintegrating films. All these achievements received high recognition from the laboratory’s expert team.

As a leading enterprise in R&D of oral dispersible film formulations in China, Jinglong Biotechnology’s R&D and production personnel possess years of experience in oral dispersible film R&D and manufacturing. The company has built a mature fully automatic oral dispersible film production line in the industry, enabling full-process industrialization from raw material preparation and process forming to quality inspection — a core advantage underlying the cooperation.

Both parties agreed during exchanges that exosomes, as natural intercellular information carriers, have great potential in the biomedicine field. However, their vulnerability to degradation by gastric acid and bile has become a critical industry bottleneck for oral formulations. Jinglong Biotechnology’s oral dispersible films enable absorption through the oral mucosa, bypassing the gastrointestinal barrier. Combined with the laboratory’s R&D technology for highly active plant exosome raw materials, this can fundamentally solve the challenges of exosome stability and bioavailability.

Based on technological complementarity and precise alignment with industry pain points, the two parties officially finalized their cooperation intention to jointly promote the R&D and industrialization of exosome (extracellular vesicle) oral dispersible films. The project will focus on the R&D of plant exosome oral dispersible film formulations. The laboratory will provide high-purity, high-activity plant exosome raw materials and molecular-level formulation design guidance, while Jinglong Biotechnology will rely on its mature oral dispersible film production experience and production lines to complete formulation process development, pilot scale-up, and GMP-compliant manufacturing, forming a full-chain cooperation model of “basic research – process development – industrialization”.

Membrane biology is a core branch of modern life sciences, mainly studying the structure and function of biological membranes and their roles in physiological and pathological processes. It is of great significance for understanding disease mechanisms, developing drug delivery systems, and solving challenging problems in the biomedicine industry.

In this cooperation, Jinglong Biotechnology will leverage its experience and production line advantages in oral dispersible films to promote the engineering transformation of the laboratory’s exosome-related research achievements. The laboratory will provide cutting-edge technical support in membrane biology for Jinglong Biotechnology, helping the company achieve innovative breakthroughs in R&D of membrane-related active ingredients and novel oral dispersible film delivery technologies, while laying a solid scientific foundation for the company to layout next-generation biotechnology.

The person in charge of R&D at Wuhan Jinglong Biotechnology stated:

“Jinglong Biotechnology has been deeply engaged in oral dispersible film R&D for many years and has built a mature dedicated production line, which is our core strength for participating in cutting-edge biomedicine R&D. This in-depth cooperation with the State Key Laboratory of Membrane Biology at Tsinghua University, and jointly advancing the exosome oral dispersible film project, has achieved an accurate integration of top-tier scientific research strength and industrial production capacity. In the future, we will fully leverage our production line and experience advantages to promote the project from laboratory to industrialization, creating an innovative paradigm for plant exosome oral formulations.”

A relevant person in charge of the State Key Laboratory of Membrane Biology at Tsinghua University expressed high expectations for the cooperation:

“Jinglong Biotechnology’s mature production experience and complete production lines in the oral dispersible film field are key supports for the industrialization of exosome research achievements. The laboratory’s technological accumulation in membrane biology and exosome R&D perfectly complements Jinglong Biotechnology’s industrial capabilities. We expect this cooperation to serve as a starting point for in-depth synergy between the two parties, jointly promoting the innovative development of exosome oral dispersible film technology and bringing new breakthroughs to the biomedicine industry.”

This in-depth cooperation with the State Key Laboratory of Membrane Biology at Tsinghua University is an important strategic move for Jinglong Biotechnology to integrate industry-university-research-application and layout cutting-edge biomedicine fields, based on its core advantages of mature oral dispersible film production experience and complete industrial production lines.

In the future, Jinglong Biotechnology will continue to leverage its technological and industrial advantages in film formulations, focus on the R&D and industrialization of exosome (extracellular vesicle) oral dispersible films, carry out full-chain and in-depth technical collaboration with the laboratory, efficiently promote key links such as project pilot scale-up and establishment of GMP production standards, and accelerate the transformation of cutting-edge scientific research achievements into industrial products.

Meanwhile, taking this cooperation as an opportunity, Jinglong Biotechnology will further deepen linkage with top scientific research institutions, continuously expand the application boundaries of film technology in the biomedicine field, promote industrial technological innovation with robust industrialization capabilities, and contribute Jinglong’s strength to the high-quality development of the biomedicine industry.